Fastscripts llc of ms4/1/2023 ![]() ![]() Ouyang, Yifang Wang, Jianchuan Hou, Yuhua Zhong, Xiaping Du, Yong Feng, Yuanping The anhydroketoses thus prepared were glycosylated and deprotected to give the disaccharides.įirst principle study of AlX (X= 3 d, 4 d, 5 d elements and Lu) dimer. The common intermediate, 1, 5-anhydro-2, 3-O-isopropylidene-beta- D-fructopyranose, was prepared from D-fructose and was converted into the D-tagatose derivative by oxidation followed by stereoselective reduction to the 4-epimer. Synthesis of 4-O-glycosylated 1, 5-anhydro- D-fructose and of 1, 5-anhydro- D-tagatose from a common intermediate 2, 3-O-isopropylidene- D-fructose.Īgoston, Károly Dékány, Gyula Lundt, Ingeįour novel disaccharides of glycosylated 1, 5-anhydro- D-ketoses have been prepared: 1, 5-anhydro- 4-O-beta- D-glucopyranosyl-D-fructose, 1, 5-anhydro- 4-O-beta- D-galactopyranosyl-D-fructose, 1, 5-anhydro- 4-O-beta- D-glucopyranosyl-D-tagatose, and 1, 5-anhydro- 4-O-beta- D-galactopyranosyl-D-tagatose. ![]() This work gives helpful suggestions on the design of novel D 3R antagonists with increased activities. Based on the steric, electrostatic, hydrophobic and hydrogen-bond acceptor information of contour maps, key structural factors affecting the bioactivity were explored. Two predictive 3 D-QSAR models have been generated for the modified design of D 3R antagonists. 3 D-QSAR studies were performed on a novel series of D 3 receptor antagonists, 1,2, 4-triazolyl 5-azaspiro -heptanes, using CoMFA and CoMSIA methods. 3 D-QSAR studies on 1,2, 4-triazolyl 5-azaspiro -heptanes as D 3R antagonistsĭopamine D 3 receptor has become an attractive target in the treatment of abused drugs.
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